M-STAR applications


Most biologic processes begin in lab-scale tabletop bioreactors with small operating volumes. Scaling up from lab-scale to production-scale can be challenging, but M-STAR CFD is here to help users achieve this transition with greater speed and fidelity than ever before. Its advanced simulation capabilities provide powerful insights into bioreactor performance, enabling optimization of processes and data-driven decision making.

State-of-the-Art Modeling Capabilities

M-STAR CFD has been designed to handle simulations with millions of grid points and millions of individually tracked bubbles. This allows users to accurately model complex bioreactor physics problems—including mass transfer, multiphase fluid flow, and more—in just minutes. The software delivers precise, actionable insights that help understand and optimize bioreactor performance.

Comprehensive Models for Bioreactor Analysis

M-STAR CFD offers a wide range of models to simulate essential bioreactor phenomena. These models include:

  • Gas hold-up: Analyze the distribution of gas bubbles within the bioreactor and optimize gas-liquid mass transfer.
  • Oxygen and CO2 transfer: Understand the efficiency of oxygen and CO2 transport within the bioreactor to optimize cell growth and productivity.
  • Chemical reactions: Simulate chemical reactions and reaction kinetics to ensure optimal conditions for bioprocesses.
  • Bubble break-up and coalescence: Investigate bubble dynamics within the bioreactor to enhance mass transfer and gas-liquid interactions.
Transform Bioreactor Scale-Up with M-STAR CFD

M-STAR CFD is the ultimate solution for modeling bioreactors, helping users transition from lab-scale to production-scale with confidence. Its advanced modeling capabilities and comprehensive range of models empower users to optimize bioreactor performance and make informed decisions during the scale-up process. Experience the power of M-STAR CFD and revolutionize bioprocess development

Agitated tanks

Mixing processes in multi-fluid systems involve a complex interplay between fluid inertia, viscosity, and buoyancy. M-STAR CFD empowers users to model and predict real-time fluid mechanics in rheologically complex laminar, transitional, and turbulent systems, providing valuable insights to optimize mixing processes inside agitated tanks.

Advanced Modeling Capabilities

M-STAR CFD is designed to run on millions and billions of lattice grid points, enabling users to rapidly and accurately model complex physics simulations. Its advanced capabilities make it the ideal tool for analyzing transport physics and blending in two-fluid, density-stratified systems. M-STAR CFD handles a wide range of phenomena, such as:

  • Complex rheology: Accurately model the viscosity and flow behavior of non-Newtonian and yield stress fluids.
  • Density stratification: Analyze the impact of density differences on fluid flow and mixing efficiency in multi-fluid systems.
  • Surface vortexing: Investigate the formation and dynamics of surface vortices and their influence on the overall mixing process.
  • Shear or energy dissipation: Understand the distribution of shear forces and energy dissipation within the agitated tank to optimize impeller design and operation.
  • Time-varying impeller speed: Simulate transient and time-dependent mixing scenarios to study the effects of variable impeller speeds on mixing performance.
  • Blend time: Estimate the time required to achieve a homogenous mixture, taking into account complex fluid dynamics and mixing parameters.
Optimize Mixing Processes with M-STAR CFD

M-STAR CFD is a powerful tool for predicting and optimizing mixing processes inside agitated tanks, offering users the ability to master the complexities of multi-fluid systems. Its advanced modeling capabilities provide unparalleled insights into fluid mechanics and transport phenomena, enabling data-driven decision-making and design optimization. Harness the power of M-STAR CFD to revolutionize your mixing process analysis and achieve better outcomes

Particle simulations

Particle-laden systems present unique challenges, requiring the simultaneous solution of fluid field, particle fields, and interactions between the two phases. M-STAR CFD’s GPU-based implementation makes large-scale simulations of such systems both accessible and practical, providing users with powerful insights to optimize their processes.

Advanced Modeling Capabilities for Particle-Laden Systems

M-STAR CFD offers a comprehensive suite of modeling capabilities specifically designed to address the complexities of particle-laden systems, including:

  • CFD-DEM Simulation: Simulate the fluid dynamics and discrete element method (DEM) simultaneously to accurately capture the behavior of particles and fluid flow in the system.
  • Two-Way Coupling: Model the interactions between particles and fluid, taking into account the effects of drag, lift, and other forces on both phases.
  • Non-Spherical Particles: Analyze the behavior of particles with irregular shapes, accounting for their unique characteristics and impact on fluid dynamics.
  • Reacting Particles: Simulate chemical reactions occurring on or between particles, as well as their influence on the fluid phase.
  • Particle Breakup: Investigate the mechanisms and consequences of particle breakup, including changes in particle size distribution and system behavior.
  • Mixing Rules: Model the interactions and blending of multiple particle types, enabling the optimization of mixing processes and prediction of system performance.

Free surface dynamics

Free surface dynamics involve the interaction between two or more immiscible fluids, typically gas-liquid or liquid-liquid systems, where the interface between the fluids plays a crucial role. M-STAR CFD provides powerful capabilities to model and analyze these complex phenomena, empowering users to tackle challenges such as sloshing, vortex formation, mass transfer, filling and draining systems, and transient solid body forces.

Key Advantages of M-STAR CFD for Free Surface Simulation

M-STAR CFD offers a comprehensive suite of features designed to address the complexities of free surface simulation, including:

  • Multiphase Flow Modeling: Accurately simulate the interactions between multiple fluid phases, capturing the behavior of immiscible fluids and their interfaces.
  • Physics Acting on Free Surfaces: Model the forces and phenomena affecting free surfaces, such as surface tension, wetting, and phase change, to gain a deeper understanding of their impact on system performance.
  • Transient Behavior Analysis: Investigate the dynamic and time-dependent aspects of free surface dynamics, including sloshing, vortex formation, and transient solid body forces.
  • Mass Transfer Modeling: Analyze mass transfer processes over the free surface, such as oxygen entrainment.
  • Filling and Draining Systems: Simulate the filling and draining of tanks or other containers, accounting for fluid dynamics, interface behavior, and the influence of solid structures.

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